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Table 1 2 × 2 contingency table for one particular gene in E. coli

From: The impact of RNA structure on coding sequence evolution in both bacteria and eukaryotes

 

Conserved sites

Non-conserved sites

Structurally sensitive

3

10

Structurally non-sensitive

4

57

  1. Note - The odds ratio of conservation pattern between structurally disruptive and non-disruptive sites is (3/10)/(4/57) = 4.28. Because there is one contingency table per gene, we applied the Mantel-Haenszel test to compute the joint odds ratio across all genes.