Position specific variation in the rate of evolution in transcription factor binding sites

Table 1 Correlation between information content and substitutions per site for the experimentally characterized binding sites in the SCPD database.

Factor	Type of DNA-binding domain (YPD)	Number of binding sites (SCPD)	Width of motif	Spearman's rank correlation	p-value
Gcn4p	BZIP	15	12	-0.84	<0.001 **
Gal4p	Zn[2]Cys[6] zinc finger	10	17	-0.83	<0.001 **
Abf1p	Atypical CHC2-type zinc finger	16	12	-0.70	0.005 *
Mcm1p	MADS box	35	14	-0.70	0.002 *
Rap1p	Myb-like	17	15	-0.72	<0.001 **
Reb1p	Myb-like	18	10	-0.81	0.002 *
Tbp1p	TATA-binding	15	9	-0.46	0.106

P-values refer to the significance of the Spearman Rank correlation coefficient. * Indicates significance at a per-factor error rate < 0.05. ** Indicates significance after Bonferoni correction to keep the global error rate < 0.05, assuming 50 tests were done in total.

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