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Table 1 Correlation between information content and substitutions per site for the experimentally characterized binding sites in the SCPD database.

From: Position specific variation in the rate of evolution in transcription factor binding sites

Factor Type of DNA-binding domain (YPD) Number of binding sites (SCPD) Width of motif Spearman's rank correlation p-value
Gcn4p BZIP 15 12 -0.84 <0.001 **
Gal4p Zn[2]Cys[6] zinc finger 10 17 -0.83 <0.001 **
Abf1p Atypical CHC2-type zinc finger 16 12 -0.70 0.005 *
Mcm1p MADS box 35 14 -0.70 0.002 *
Rap1p Myb-like 17 15 -0.72 <0.001 **
Reb1p Myb-like 18 10 -0.81 0.002 *
Tbp1p TATA-binding 15 9 -0.46 0.106
  1. P-values refer to the significance of the Spearman Rank correlation coefficient. * Indicates significance at a per-factor error rate < 0.05. ** Indicates significance after Bonferoni correction to keep the global error rate < 0.05, assuming 50 tests were done in total.