Figure 7
From: Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
Frequency distribution of the epistasis parameter β for measured w(d) and for wneut(d), the latter obtained using two different methods (M1 and M2) to remove the effect of compensatory mutations on w(d). Both methods shift the distribution such that it is roughly centered around 1, in contrast to the strong bias toward antagonism (β < 1) when compensatory mutations are included.