Erratum to: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly

Removal of redundant entries resulted in a substantial decrease in the number of protein-protein interactions per S. cerevisiae protein (Figure 1). However, consideration of this revised data with respect to evolutionary rates does not result in any qualitative change in the results or conclusions of our previous report. A total of 2,807 pairs of orthologous proteins, one from S. cerevisiae and one from S. pombe, were identified, and for 1,061 of these, there was data on protein-protein interactions of the S. cerevisiae member in the corrected MIPS data. There appears to be no simple dependence between protein evolution rate and the number of protein-protein interactions; in fact, the slight negative correlation between the number of interactions and the evolutionary rates is no longer statistically significant with the corrected data (Figure 1 and Table 1). There is no significant correlation between the taxonomic distribution of S. cerevisiae orthologs and the number of protein-protein interactions (r² = 0.0004, p = 0.5). The apparent trend whereby the most prolific S. cerevisiae interactors have, on average, lower evolutionary rates than proteins that are involved in fewer protein-protein interactions also remains (Figure 2 and Table 2).