Erratum to: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly
- I King Jordan1,
- Yuri I Wolf1 and
- Eugene V Koonin1Email author
https://doi.org/10.1186/1471-2148-3-5
© Jordan et al; licensee BioMed Central Ltd. 2003
Received: 25 March 2003
Accepted: 2 April 2003
Published: 2 April 2003
The original article was published in BMC Evolutionary Biology 2003 3:1
After the publication of this work [1], we became aware of the fact that the Saccharomyces cerevisiae physical interaction table from the MIPS database that was used to count the number of protein-protein interactions per S. cerevisiae protein contains numerous redundant entries http://mips.gsf.de/proj/yeast/tables/interaction/physical_interact.html. These redundancies were not removed initially, and as a result the numbers of protein-protein interactions reported for S. cerevisiae proteins and compared to the proteins' evolutionary rates were artifactually high. These redundancies have now been removed and the data has been re-analyzed. Here we briefly present the results of the re-analysis with the corrected data sets along with revisions of the relevant tables and figures.
The relationship between the number of protein-protein interactions for S. cerevisiae proteins and the evolutionary rates between S. cerevisiae and S. pombe orthologs. Shown for each plot is the equation that describes the linear trend line, the r2 value that describes the fraction of the variability in the evolutionary rates that is accounted for by the variability in the number of protein-protein interactions and the p value, which is the probability that the correlation between the number of protein-protein interactions and evolutionary rates could be due to chance. (a) All 1,061 observations. (b) 478 observations that correspond to orthologous protein pairs with = 40% amino acid sequence identity.
Mean evolutionary rates between S. cerevisiae and S. pombe orthologs for bins of proteins with different numbers of interactions. The range of the number protein-protein interactions per S. cerevisiae protein for each bin (x-axis) and the mean evolutionary rate (substitutions per site) for each bin (y-axis).
Correlation between the number of protein-protein interactions and the evolutionary rate.
Data set | Linear correlation coefficient (r)/ P-value | Rank correlation coefficient (R)/P-value |
---|---|---|
S. cerevisiae – S. pombe(all orthologs, N = 1061) | -0.051/0.095 | 0.022/0.47 |
S. cerevisiae – S. pombe(only orthologs with > 40% identity, N = 478) | 0.011/0.812 | 0.096/0.036 |
H. pylori J99 – H. pylori 26695 (N = 672) | -0.039/0.310 | 0.020/0.610 |
H. pylori – C. jejuni(N = 458) | -0.013/0.787 | 0.015/0.747 |
Statistical significance of the differences in evolutionary rates between groups of proteins with different numbers of interactions.
Bin (# interactions) comparisons a | P b |
---|---|
S. cerevisiae – S. pombe | |
16 – 29 vs. 1 – 15 | 1.0 × 10-2 |
11 – 29 vs. 1 – 10 | 5.9 × 10-3 |
6 – 29 vs. 1 – 5 | 5.2 × 10-1 |
H. pylori 26695 – H. pylori J99 | |
21 – 55 vs. 1 – 20 | 1.5 × 10-1 |
15 – 55 vs. 1 – 14 | 1.8 × 10-1 |
11 – 55 vs. 1 – 10 | 3.2 × 10-1 |
H. pylori 26695 – C. jejuni | |
21 – 47 vs. 1 – 20 | 9.8 × 10-1 |
11 – 47 vs. 1 – 10 | 5.1 × 10-1 |
We regret any inconvenience that this inaccuracy in the data used for the original analysis might have caused. We wish to thank Dr. Hunter B. Fraser for bringing this matter to our attention.
Notes
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Authors’ Affiliations
References
- Jordan IK, Wolf YI, Koonin EV: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol. 2003, 3: 1-10.1186/1471-2148-3-1.PubMed CentralView ArticlePubMedGoogle Scholar
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