Distribution of one-step (red) and two-step (green) detoxification pathways of SAH within the three domains of life. All sequences shown in the tree could be found in the ARB database (ssujun02.arb), hence were already aligned, and for the desired presentation were all transferred to the rudimentary tree (tree_demo) by the ARB function "quick add by parsimony". After marking all species (sequences) of interest only these were kept by removing all unmarked species with an integrated ARB function. This leaves the original topology of the tree intact while eliminating all species and branches which are unnecessary for the demonstration of the phylogenetic distribution of sequences of prime interest. Phyla are numbered from 1 to 13. 1 Gammaproteobacteria; 2 Betaproteobacteria; 3 Alphaproteobacteria; 4 Epsilonproteobacteria; 5 Spirochaetes; 6 Chlorobia; 7 Bacteroidetes; 8 Cyanobacteria; 9 Actinobacteria; 10 Firmicutes; 11 Deinococcus-Thermus; 12 Thermotogae; 13 Aquificae. Numbers in brackets indicate sequenced genomes analysed. Shaded phyla are mixed, having organisms with the SahH pathway and organisms with the Pfs/LuxS pathway. Boxed strains have both LuxS and SahH.