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Figure 5 | BMC Evolutionary Biology

Figure 5

From: Upstream plasticity and downstream robustness in evolution of molecular networks

Figure 5

Divergence of physical interaction neighborhoods of duplicated genes in a bacterium H. pylori and a fly D. melanogaster. The average value of the interaction overlap Ω int of paralogous proteins in H. pylori (A) and D. melanogaster (B) as a function of the amino acid sequence similarity. The physical interaction data are taken from Ref. [6] for H. pylori (A) and from Ref. [7] for D. melanogaster. Note the apparent plateau for PID's between 50% and 100% in panel A and its absence in panel B. Dashed horizontal lines show the average interaction overlap of a random (usually non-paralogous) pair of proteins. The solid line in B is the best fit to the exponential form: Ω int ~ exp(γ FLY PID) with γ fly = 0.045.

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