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Table 1 List of the names of 59 test protein families together with their CDD accession names, lengths, number of protein pairs, Pearson correlation coefficients between LHM (AHM) and normalized Blast bitscore. The families are ordered with respect to decreasing quality of LHM correlation. The supplementary table is available at [27].

From: Structural similarity of loops in protein families: toward the understanding of protein evolution

Family name

CDD acc

Length

#Obs

AHM

LHM

Xylose_isom

pfam00259

381

28

-0.99

-0.98

MHC_I

pfam00129

175

28

-0.95

-0.96

PTPc

smart00194

248

25

-0.92

-0.96

IPT

smart00429

97

21

-0.90

-0.94

ZnMc_1

smart00235

137

34

-0.83

-0.94

RNAse_Pc

cd00163

99

25

-0.82

-0.94

gpdh_C

pfam02800

153

39

-0.72

-0.93

Aamy_C

smart00632

81

31

-0.94

-0.90

peroxidase

pfam00141

240

48

-0.90

-0.90

copper-bind

pfam00127

81

87

-0.84

-0.89

CBM_20

pfam00686

94

15

-0.91

-0.89

RnaseA

pfam00074

98

44

-0.48

-0.87

IGv

cd00099

105

133

-0.78

-0.86

ADH_zinc_N

pfam00107

337

64

-0.93

-0.86

ldh_C

pfam02866

143

29

-0.93

-0.86

RIP

pfam00161

232

28

-0.87

-0.85

Peptidase_C1

pfam00112

200

55

-0.82

-0.85

ZnMc_2

cd00203

134

23

-0.87

-0.85

PROF

cd00148

120

15

-0.90

-0.85

plant_peroxidase

cd00314

236

76

-0.90

-0.83

alpha-amylase_C

pfam02806

78

39

-0.93

-0.82

sodcu

pfam00080

139

15

-0.98

-0.81

fer2_1

cd00207

78

38

-0.86

-0.80

Pept_C1

smart00645

202

90

-0.86

-0.79

ferritin

pfam00210

152

19

-0.94

-0.79

ldh

pfam00056

135

44

-0.82

-0.78

SH2

pfam00017

86

21

-0.48

-0.78

flavodoxin

pfam00258

143

26

-0.88

-0.78

EFh

cd00051

57

59

-0.75

-0.77

rhv_1

cd00205

195

71

-0.86

-0.76

LYZ1_1

smart00263

116

67

-0.66

-0.75

aldo_ket_red

pfam00248

277

28

-0.93

-0.73

COesterase

pfam00135

485

28

-0.80

-0.72

TIG

pfam01833

89

39

-0.90

-0.72

fer2_2

pfam00111

69

73

-0.77

-0.70

beta-lactamase

pfam00144

264

45

-0.90

-0.70

rhv_2

pfam00073

216

95

-0.86

-0.70

GLECT

cd00070

124

28

-0.80

-0.67

globin

pfam00042

133

96

-0.74

-0.66

GST_C

pfam00043

107

77

-0.77

-0.63

LYZ1_2

cd00119

109

24

-0.43

-0.61

PA2c

smart00085

102

210

-0.29

-0.57

lipocalin

pfam00061

131

55

-0.62

-0.56

phoslip

pfam00068

102

102

-0.21

-0.54

proteasome

pfam00227

189

56

-0.80

-0.51

UBCc

smart00212

141

45

-0.79

-0.50

Sm

smart00651

63

30

-0.54

-0.49

Tryp_SPc

smart00020

208

561

-0.55

-0.46

CLECT_1

smart00034

90

35

-0.59

-0.44

crystall

pfam00030

81

10

-0.76

-0.41

CLECT_2

cd00037

93

263

-0.45

-0.36

RHO

smart00174

173

10

-0.52

-0.36

IGc1

cd00098

88

85

-0.65

-0.32

Tryp_SPc

cd00190

211

378

-0.55

-0.31

MHC_II_beta

pfam00969

86

32

-0.52

-0.26

ADK

pfam00406

174

28

-0.37

-0.19

Rho

cd00157

172

66

-0.20

-0.16

Phycobilisome

pfam00502

148

15

-0.85

-0.10

ADF

smart00102

116

10

-0.85

0.34