Figure 2

A phylogenetic tree for Sin1 primary sequences from various species. Sin1 polypeptide sequences were aligned by the program ClustalW, and the alignment output used by the program MEGA to generate a neighbor joining phylogenetic tree for the regions of alignment. GeneBank accession numbers for Sin1 sequences are listed in Table 1. Numbers beside branch points indicate the confidence levels for the relationship of the paired sequences as determined by bootstrap statistical analysis (1000 replicates). The lengths of the arms represent the extent of amino acid differences between the paired sequences, with the scale bar equivalent to 50 residues.