Figure 4

Driving force behind fusion proteins. (a) Nesting toward the innermost core for the eukaryotes S. cerevisiae, C. elegans, D. melanogaster, M. musculus and H. sapiens we find that the co-occurrence links increasingly coincide with links in the Yeast protein domain interaction network. (b) The interaction strength s of domains is the sum of the interaction weights of all links a domain is involved in the corresponding cores of the respective co-occurrence networks. Averaging over the size of the corresponding cores, the average interaction strength decreases toward the innermost cores.