Table 2 Five most connected domains in the innermost core-layers using their degree k in the full domain networks of S. cerevisiae, C. elegans, D. melanogaster, M. musculus and H. sapiens. Notably, the innermost layer l (equivalent to the innermost core) is not populated by the largest hubs, indicating that a high degree alone does not necessarily imply a central placement in the network. In fact, we observe that with even a considerably low degree k domains are placed in the inner cores, a domain specific feature we call globally central. We also observe highly connected domains that only make it to the outer cores, indicating a locally central position in the respective networks.

From: Evolutionary cores of domain co-occurrence networks