Table 2 For simulation A the final average (over 10 different peptides each repeated 10 times) frequency of each fate across generations is reported. Error bars are reported as the standard error of the mean.

1

40.27 ± 1.10

0.01 ± 0.01

8.71 ± 0.90

0.23 ± 0.08

0.00 ± 0.00

0.00 ± 0.00

949.11 ± 1.37

20

360.89 ± 5.67

1.80 ± 0.24

127.72 ± 0.59

10.22 ± 0.88

0.37 ± 0.10

0.11 ± 0.04

469.49 ± 9.90

40

421.28 ± 6.83

4.41 ± 0.50

217.26 ± 13.95

18.54 ± 1.49

3.63 ± 0.75

1.55 ± 0.31

294.25 ± 10.85

60

410.64 ± 7.58

5.95 ± 0.53

294.73 ± 14.91

25.71 ± 1.99

7.57 ± 1.10

2.86 ± 0.48

209.70 ± 9.83

80

381.06 ± 7.72

7.47 ± 0.59

356.11 ± 14.76

29.03 ± 2.09

14.37 ± 1.67

5.21 ± 0.75

161.78 ± 9.00

100

352.85 ± 8.02

8.02 ± 0.61

402.22 ± 14.33

30.66 ± 2.33

24.05 ± 2.37

7.46 ± 0.95

128.69 ± 7.76

120

329.56 ± 7.83

9.32 ± 0.79

432.93 ± 14.01

32.30 ± 2.73

31.85 ± 2.95

8.14 ± 1.08

109.06 ± 6.94

140

312.37 ± 6.97

10.15 ± 0.93

450.22 ± 13.10

30.22 ± 2.69

43.83 ± 3.24

12.14 ± 1.49

93.30 ± 5.98

160

291.73 ± 7.02

10.33 ± 0.83

473.25 ± 12.97

29.06 ± 2.69

49.20 ± 3.77

13.92 ± 1.72

83.90 ± 5.23

180

284.48 ± 6.47

11.58 ± 0.84

478.46 ± 12.60

27.93 ± 2.51

57.99 ± 4.42

14.78 ± 2.03

76.08 ± 4.81

200

274.61 ± 6.18

12.51 ± 1.00

481.93 ± 12.78

27.62 ± 2.68

68.17 ± 4.70

16.09 ± 2.27

71.22 ± 4.35