Figure 3

Alignment of the refined Ciona α chain sequences with representative human orthologues (residues 1-391 based on human α1 integrin chain). Protein domains and conserved motifs are annotated. Levels of sequence conservation are indicated (>50% identical, red; conservative substitutions, blue). MIDAS and α C-helix within the inserted A-domain are highlighted, as are the β-propeller domains 1–3.