Figure 6

Alignment of the refined Ciona β chain sequences with representative human orthologues (residues 1-542 based on the human β1 integrin chain). Protein domains and conserved motifs are annotated. Levels of sequence conservation are indicated (>50% identical, red; conservative substitutions, blue). Adjacent to MIDAS (AMIDAS), ligand associated metal binding site (LIMBS) and MIDAS cation binding sites, and interaction motifs are highlighted as are the plexin/semaphorin/integrin (PSI), β-A domain (I-like) and epidermal growth factor (EGF) domains 1–2.