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Table 3 Paralogous gene families expanded in DR

From: Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistance

Description

COG numbers

Number of representatives in DR

Number of representatives in TT

Widespread families expanded in DR

MutT-like phosphohydrolases (Nudix)

COG0494, COG1051

17,5

5,5

Calcineurin-like phosphoesterase

COG1768, COG1408, COG1692, COG0639

1; 1; 1; 9

1; 0; 1; 2

Lipase-like alpha/beta hydrolase

COG0596, COG0400

10; 1

6; 1

Subtilisin-like protease

COG1404

10

2

Sugar deacetylase

COG2120

6

4

PadR-like transcriptional regulators (possibly involved in chemical stress response)

COG1695

9

0

MOSC sulfur-carrier domains

COG2258

4

1

FlaR like kinases

-

3

0

LigT phosphatases (may participate in RNA repair or methabolism)

-

3

2

McrA endonuclease

COG1403

5

1

TerZ family (could confer resistance to a variety of DNA-damaging agents)

COG2310

7

0

PR1 family (stress response)

COG2340

5

1

DinB family (DNA damage and stress inducible proteins)

COG2318; no COG

3; 10

1

Transcriptional regulators

-

5

0

Unique DR families

GRXGG repeats containing protein

-

DR0082, DR2593, DR1748

No

Alpha/beta proteins, tryptophan-rich

-

DR2532, DR2457

No

Proteins with GXTXXXG and CXPXXXC motifs (DR0871 has duplication of the domain)

-

DR0871, DR1920, DR2360

No

Secreted alpha/beta proteins with a single conserved domain

-

DR1251, DR1319, DR1545

No

Predominantly alpha-helical proteins

-

DR0481, DR1195, DR1301

No

Predominantly alpha-helical proteins

-

DR0387, DR2038+DR2039

No

Predicted metabolic regulator containing V4R domain

-

DR2179, DR1611

No

Predicted sirohydrochlorin cobaltochelatase

COG2138

DRA0012, DR2241

No

Conserved histidine rich protein (now also found in Caulobacter and Mesorhizobium)

COG3798

DR1261, DR1348

No