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Table 12 Summary of coiled-coil protein functions

From: Coiled-coil protein composition of 22 proteomes – differences and common themes in subcellular infrastructure and traffic control

Functional groups of coiled-coil proteins Examples Species represented
Chromatin organization and maintenance, chromosome segregation and DNA repair SMCs, Rad50, SbcC, MukB, MutS all kingdoms
Transcription and translation Transcription and translation initiation factors, reverse transcriptase all kingdoms
Protein trafficking and quality control Chaperonins, secretion proteins prokaryotes and organelles
Membrane sensors, channels and regulation of influx/export MCPs, ion channels prokaryotes
Sensor mechanisms and signal transduction Receptor kinases, GTPases eukaryotes – conserved, as well as plant and animal specific
Compartmentalization, stabilization and dynamics of membrane systems Golgins, SNAREs, endocytic proteins eukaryotes
Adherence Cell adherence, extracellular matrix, intracellular adapters eukaryotes and parasitic prokaryotes
Mechanical fiber and meshwork formation Keratin, intermediate filaments, flagellar (e.g. sperm tail) proteins eukaryotes, keratin only in mammals
Motility Muscle fibers, cell motility, actin and microtubule motors eukaryotes
Organization, stabilization and dynamics of the cytoskeleton Actin and microtubule crosslinkers eukaryotes, predominantly metazoa
Mitotic spindle assembly and checkpoint control Centrosome, kinetochore and spindle pole body proteins metazoa and yeast