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Table 8 Animal-specific clusters

From: Coiled-coil protein composition of 22 proteomes – differences and common themes in subcellular infrastructure and traffic control

Cluster size
(# of sequences)
Max. edge
protein family putative function/site of action organism
39 9.9E-7 Spectrins, Dystrophin, Nesprins membrane/actin/MT crosslinkers (cytoskeleton) C.e., D.m., H.s., M.m.
32 <E-40 Laminins scaffold protein (extracellular matrix) C.e., D.m., H.s., M.m.
25 6.7E-8 Plectin/Desmoplakin actin/MT crosslinkers (cytoskeleton) C.e., D.m., H.s., M.m.
22 6.5E-8 Myosin heavy chain (muscle) actin motor protein, muscle fibers C.e., D.m., H.s., M.m.
18 9.3E-9 Lamins nuclear IFs C.e., D.m., H.s., M.m.
17 5.8E-7 Neurofilament triplet L, M, Death inducer, Troponin T   C.e., D.m., M.m., H.s.
14 7.5E-7 Neurofilament triplet H, M   C.e., D.m., H.s., M.m.
14 7.5E-7 Neurofilaments (Desmin, Vimentin) IFs C.e., H.s., M.m.
13 2.6E-7 PP1, ASPP apoptosis stimulating D.m., H.s., M.m.
12 <E-40 Moesin, Ezrin, Radixin membrane organization and stabilization (membrane cytoskeleton, cytovilli) C.e., D.m, H.s., M.m.
11 1.7E-43 RUFY possible role in vesicle trafficking (endosomes?) D.m., H.s., M.m.
11 2.2E-11 Lamins nuclear IFs D.m., H.s., M.m.
11 3.4E-7 Restin, Dynactin, CLIP proteins linking endocytic vesicles to MTs (IF cytoskeleton), dynein activator (MTs in neurons), MT/IF associated (cytoskeleton) C.e., D.m., H.s., M.m.
11 3.9E-7 Png-1, Neurofilament triplet M, Troponin T   C.e., D.m., H.s., M.m.
10 <E-40 Dystrophins   C.e., D.m., H.s., M.m.
10 2.7E-8 prion-like protein   C.e., D.m.
  1. Numbers include "bridge" sequences qualifying for more than one cluster. Only clusters represented by at least 10 sequences are listed. ASPP, apoptosis stimulating of p53 protein [127]; PP1, protein phosphatase 1 [128]; RUFY, RUN and FYVE domain containing proteins [129]. For species name abbreviations, see Table 1.