Figure 6

The AS-C in A. gambiae. A) Alignment of the achaete-scute homologous protein of A. gambiae (A.g.Ash; [36]) with melanogaster L'sc and Sc proteins. Note the high conservation of the bHLH domain (purple) and the very C-terminus. Comparison over the entire length gives a higher identity score to D.m.L'sc, however, the alignment shows also regions that are more similar to D.m.Sc. B) Alignment of the neighbouring bHLH gene product from A. gambiae with D. melanogaster Ase. The alignment is shown to A.g.Ase/i (database predicted version without intron) and A.g.Ase (second intron translated). The second predicted intron comprises almost 2.5 kb and ends with an exon translated into five residues (CSPTH; in A.g.Ase/i). Translation into this intron leads to A.g.Ase that is similar in size and in its terminus to D.m.Ase. Highest conservation is found in the bHLH domain (purple). Identical residues are marked in blue; red shows highly related and yellow similar residues.