The neighbor-joining tree of the ERM family. The diagram illustrates the basic resolution of the ERM-family members into two major clades, merlin and ERM. Bootstrap support values are shown above each node. Shaded boxes denote different subgroups of the ERM clade in vertebrates, which appeared after the expansion of the ERM-like ancestor. The Tetraodon nigroviridis "unnamed protein 1 and 2" sequences (GenBank Accession No. CAG08868 and CAG08250, respectively) and the Xenopus laevis "unknown protein" sequence (GenBank Accession No. AAH77822) were grouped based on their similarity to the merlin or ERM sequences.