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Table 5 Average GO similarity for species-specific mammalian gene coexpression networks versus average GO similarity for the conserved human-mouse intersection network

From: Global similarity and local divergence in human and mouse gene co-expression networks

Network

GOavg 1

t 2

P 3

Human-specific

0.2556 ± 9.3e-4

25.65

3.3e-144

Mouse-specific

0.2678 ± 9.2e-4

20.31

2.2e-91

Intersection

0.3299 ± 3.4e-3

  
  1. 1Average GO similarities for all pairs of genes connected by an edge in the coexpression network
  2. 2Value of the test statistic for the comparison between the species-specific network and the intersection network, t = (μ1-μ2)/(σd*sqrt(1/n1+1/n2)) where μ are the respective means and σd is the standard deviation of the difference
  3. 3Level of significance, i.e., probability that the distributions of GO similarity values for the intersection and species-specific networks are identical, based on Students t-distribution with degrees of freedom = n 1+n 2-2
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BMC Ecology and Evolution

ISSN: 2730-7182

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