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Table 1 List of Ligands

From: Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

Liganda

Recb

Speciesc

amphiregulin (AR)

E1

c, ch, co, d, es, f, h, m, ma, o, p, r, ra, rh, rt(2), t, xt, z

betacellulin (BTC)

E1, E4

ae, c, ca, ch, co, d, es, f, h, m, p, r, ra rh, s, t, xt, z

epidermal growth factor (EGF)

E1

ae, c, ch, ct, d, dn, et, f, h, m, me, o, p, r, t, xt, z

epigen

E1

c, ch, co, d, h, m, o, r, ra, xl(2), xt, z

epiregulin (EPR)

E1, E4

c, ch, co, d, f, h, m, me(2), o, r, ra, rh, rt(2), t, xt, zf

gurken

I

da, de, di, dm, dp, dr, ds, dw, dy

heparin-binding epidermal growth factor (HB-EGF)

E1, E4

c, eg, ch, co, d, f, gm, h, m, ma, me, o, p, r, ra, rt, st, t, xt, z

interphotoreceptor matrix proteoglycan-2 (IMP2)

UN

c, ch, co, d, f, h, m, o, r, rh, t, xt, z

keren

I

da, de, dg, di, dj, dm, dp, dr, ds, dv, dw, dy, g

lin3

I

cb, ce

meprin 1α (MEP1α)

UN

ae, c, ch, d, dn, f, h, m, o, r, rh, t, xl, xt, z

meprin 1β (MEP1β)

UN

c, ch, co, d, f, h, m, o, p, r, rh, t, xl(2), xt, z

mucin 3 (MUC3)

UN

co, h, m, r, rh, rt, xt(3), z

mucin 4 (MUC4)

P

c, co, d, h, m, o, r, xt

mucin 12 (MUC12)

UN

c, co, d, h, m, ra, rh

mucin 17 (MUC17)

UN

d, et, h, m, o, r, rh

neuregulin-1α (NRG1α)

E3, E4

ch, co, d, dn, gu, h, m, ma, o, p, r, ra, rt, xl, z

neuregulin-1β (NRG1β)

E3, E4

c, ch, co, d, h, m, o, r, xl, z

neuregulin-2α (NRG2α)

E3, E4

c, ch, co, d, et, f, gu, h, m, o, r, rh, t, z

neuregulin-2β (NRG2β)

E3, E4

c, ch, co, d, et, f, gu, h, m, o, r, rh, z

neuregulin-3 (NRG3)

E4

c, ch, co, d, es, f, gu, h, m, o, p, r, t, xt, z(2)

neuregulin-4 (NRG4)

E4

c, ch, co, f, gu, h, m, me, o, p, r, rh, rt, xt

neuroglycan-C (NGC)

E3

ab, c, ch, co, d, f, h, m, me(2), o, r, rh, sh, xt, z

spitz

I

an, da, de, dg, di, dj, dm, dp, dr, ds, dw, dv, dy, hb, 1, tc, yf

tomoregulin-1 (TR1)

E4

c, ch, co, d, dn, es, et, f, h, m, o, p, r, xl, xt, z(2)

tomoregulin-2 (TR2)

E4

c, ch, co, d, f, h, m, o, p, r, rh, rt, t(2), xl, xt, z

transforming growth factor α (TGFα)

E1

aa, ae, c, ch, co, d, dn, f, h, m, ma, o, or, p, r, ra, rh, sh, t, xl(2), xt(2), z

vein

I

an, da, de, dg, di, dj, dm, dp, dr, ds, dv, dy, hb, yf

viral growth factor

V

ar, be; bp(2); cl(2), cp, ep(5), fp(2), gp(2), ls(2), mp, my, rf, rp, sa, sp(3), va(4), vc(5), yl

  1. a List of ligands used in the evolutionary analysis. In parentheses are the abbreviated names used in the text and figures.
  2. b Indication of the receptor that each ligand binds to. E1: EGF receptor; E3: ErbB3; E4: ErbB4; I: the invertebrate ligands bind to the one invertebrate receptor; P: interacts with ErbB2, but it is unknown if it is as a typical ligand; V: the receptor specificity varies and depends on the origin of the poxvirus growth factor; UN: the receptor specificity for these potential ligands is unknown.
  3. c List of species for each ligand. The number in parentheses indicates the number of copies of the ligand found in that species or in the case of the viral growth factors the number of viral strains. The abbreviations used are as follows:
  4. aa: Arvicanthis ansorgei; ab: Astatotilapia burtoni; ae: Loxodonta africana (African elephant); an: Anopheles gambiae (African malaria mosquito); ar: aracatuba; be: BeAn58058; bp: cowpox; c: Pan troglodytes (chimp); ca: Cyprinus carpio (carp); cb: Caenorhabditis briggsae; ce: Caenorhabditis elegans; cg: Cricetulus grises (Chinese hamster); ch: Gallus gallus (chicken); cl: camelpox; co: Bos taurus (cow); cp: canarypox; ct: Felis catus (cat); d: Canis familiaris (dog); da: Drosophila ananasse; de: Drosophila erectus; dg: Drosophila gritnshawi; di: Drosophila sitnulans; dj: Drosophila mojavensis; dm: Drosophila melanogaster, dn: Dasypus novemcinctus (armadillo); dp: Drosophila pseudoobscura; dr: Drosophila persimilis; ds: Drosophila sechellia; dv: Drosophila virilis; dw: Drosophila willistoni; dy: Drosophila yakuba; ep: ectromelia; es: Sorex araneus (European shrew); et: Echinops telfaira (small Madagascar hedgehog); f: Takifugu rubripes (fugu); fp: fowlpox; g: Glossina morsitans (tsetse fly); gm: Cercopithecus aethiops (green monkey); gp: goatpox; gu: Cavia porcellus (guinea pig); h: Homo sapiens (human); hb: Apis mellifera (honey bee); 1: Homerus americanus (American lobster); Is: lumpy skin disease; m: Mus musculus (mouse); ma: Mesocricetus auratus (golden hamster); me: Oryzias latipes (medaka); mp: monkeypox; my: myxoma; o: Monodelphis domestica (opossum); or: Pongo pygmaeus (orangutan); p: Sus scrofa (pig); r: Rattus novegicus (rat); ra: Oryctolagus cuniculus (rabbit); rf: rabbit fibroma; rh: Macaca mulatta (rhesus monkey); rp: rabbitpox; rt: Oncorhynchus mykiss (rainbow trout); s: Salmo salar (salmon); sa: SPAN232; sh: Ovis aries (sheep); sp: sheeppox; st: Gasterosteus aculeatus (stickleback); t: Tetraodon nigroviridis (tetraodon); tc: Tibolium castaneum; va: variola; vc: vaccinia; xl: Xenopus laevis; xt: Xenopus tropicalis; yf: Aedes aegypti (yellow fever mosquito); yl: yaba-like; z: Danio rerio (zebrafish)