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Table 3 Ligand/Receptor Interactions

From: Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

 

EGFR

ErbB2

ErbB3

ErbB4

EGF

TGFα

#a

tet

tel

tet

tel

tet

tel

tet

tel

  

45

Tyr

His/Tyr

Tyr

His

Leu

Gln/Met

Ser

Ser

Met/Ile

Arg

90

Glub

Gluc

Glud

var

Aspe

Gluf

Glu

Glu

Lys

Lys

350

Val

Thr

Glu

var

Thrg

Thrh

Thr

Thr

Leu

Phe

355

Asp

Asp

Aspi

Aspi

Asp

Asp

Asp

Asp

Arg

Arg

357

Phe

Tyrj

var

var

Trp

Phe/Tyr

Tyr

Tyrk

Tyr

Phe

384

Gln

Gln

Serl

Gln

Gluf

Gln

Gln

Gln

Gln/Arg

Glu

  1. a: EGFR residue number
  2. b: Asp in chicken, Lys in X. tropicalis
  3. c: Asp in tetraodon
  4. d: Gln in X. tropicalis
  5. e: Glu in chicken
  6. f: Asp in zebrafish
  7. g: Ile in X. tropicalis
  8. h: Leu in zebrafish
  9. i: Asn in mouse, golden hamster, and zebrafish
  10. j: His in zebrafish
  11. k: Phe in zebrafish
  12. l: Glu in X. tropicalis
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BMC Ecology and Evolution

ISSN: 2730-7182

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