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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Stable evolutionary signal in a Yeast protein interaction network

Figure 1

(a) Pooling proteins according to their level of interaction k we determined the excess retention ER of these grouped protein (pair)s that have orthologs in H. sapiens, M. musculus, D. melanogaster, C. elegans and A. thaliana. Averaging these k depending values of ER k in bins of logarithmic size we observe clear logarithmic trends. (b) Analogously, we pooled interacting protein pairs v, w of Yeast according to their hypergeometric clustering coefficient C vw and determined the excess retention ER in these groups of protein pairs that both have orthologs in the aforementioned higher eukaryotes. Pooling these C vw dependent values of ER in bins of logarithmically increasing size we observe clear logarithmic trends again. In both cases, significant Pearson's and Spearman's rank correlation coefficients [see Additional file 1] support our conclusion that not only highly interacting proteins (as exemplified by a large k) are predominately preserved but also interacting protein pairs which are embedded in a highly cohesive neighborhood (as exemplified by a high C vw ). Error bars indicate the standard deviations from the mean excess retention in each bin.

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