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Table 2 Paired genes present in both the PE and PPE multigene families.*

From: Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions

Sub-Lineage** Paired genes Associated ESAT-6 (esx) gene cluster region***
  (PE) (PPE)  
I Rv3872 Rv3873 Situated in ESAT-6 (esx) gene cluster region 1
II Rv0285 Rv0286 Situated in ESAT-6 (esx) gene cluster region 3
II Rv3018A Rv3018c Duplicated from ESAT-6 (esx) gene cluster region 3
II Rv3022A Rv3021/22c Duplicated from ESAT-6 (esx) gene cluster region 3
II Rv1386 Rv1387 Associated with ESAT-6 (esx) gene cluster region 3
III Rv3893c Rv3892c Situated in ESAT-6 (esx) gene cluster region 2
III Rv2107 Rv2108 Associated with ESAT-6 (esx) gene cluster region 2
III or IV Rv2431c Rv2430c Associated with ESAT-6 (esx) gene cluster region 2 or 5
IV Rv1788/91 Rv1787/89/90 Situated in ESAT-6 (esx) gene cluster region 5
IV Rv3622c Rv3621c Duplicated from ESAT-6 (esx) gene cluster region 5
IV Rv1195 Rv1196 Duplicated from ESAT-6 (esx) gene cluster region 5
IV Rv1040c Rv1039c Duplicated from ESAT-6 (esx) gene cluster region 5
IV Rv1169c Rv1168c Associated with ESAT-6 (esx) gene cluster region 5
IV Rv1806 Rv1801/2/7/8/9 Associated with ESAT-6 (esx) gene cluster region 5
IV Rv3477 Rv3478 Associated with ESAT-6 (esx) gene cluster region 5
IV Rv2769c Rv2768c/70c Associated with ESAT-6 (esx) gene cluster region 5
IV Rv0916c Rv0915c Associated with ESAT-6 (esx) gene cluster region 5
  1. * Although they are physically-separated, Rv3746c and Rv3739c seems to have been a pair associated with either ESAT-6 gene cluster region 1 or 3, which was disrupted by the insertion of a number of genes.
  2. ** See Figure 5 and 6 for definition of sublineages.
  3. *** "Situated in" denotes genes situated within ESAT-6 (esx) gene cluster regions, "Duplicated from" denotes genes confirmed to be duplicated from ESAT-6 (esx) gene clusters due to the presence of ESAT-6 and CFP-10 genes immediately adjacent to them, "Associated with" denotes genes which are hypothesized to have been duplicated from ESAT-6 (esx) gene cluster regions, as they are very homologous to their paralogues within the clusters (see Figure 1).