Figure 3From: Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypesThe molecular clock analysis of MC1 (open circle), MC2 (filled triangle), MC3 (open square), MC4 (asterisk) and MC5 (filled diamond) receptor subtypes. Full-length amino acid sequences were used for the calculations. The distances were calculated with Tree-Puzzle v 5.2. Lamprey MCa (open circle) and MCb (asterisk) are plotted at 564 Myr ago. We used the following divergence times from human: mouse – 90(70), chicken – 310(310), zebrafish – 450(420), dogfish – 528 (420) and lamprey – 564 (525) Myr ago. The corresponding calculated distances were plotted against molecular and fossil data for each receptor subtype separately. The lines are linear regression lines.Back to article page