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Figure 7 | BMC Evolutionary Biology

Figure 7

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

Figure 7

Four additional human genes share homology with β subunits in both sequence and genomic organization. A) BLASTP searches of the human genome using sodium channel β subunit amino acid sequences identified significant homology to myelin P0 protein (MPZ), myelin P0 protein-like protein isoform A (MPZL1 isoform A), epithelial V-like antigen 1 (EVA1), and epithelial V-like antigen 1-like gene (EVA1L), all of which are single transmembrane proteins with extracellular V-type immunoglobulin domains and intracellular C-terminal tails as predicted by NCBI conserved domain database v2.09 and TMPred (see Methods for further details). B) This group of genes additionally shares similar genomic organization. Numbers in grey boxes refer to exon size (nucleotides) with untranslated sequence excluded for clarity.

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