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Table 1 Comparative genomics of the sodium channel β1 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene Genbank accession number gene location cDNA exon1 exon2 exon 3 exon 4 exon 5 exon6 protein %ID (%SIM) topology
zβ1A DQ489722 Chr 16 1411 219 (52) 167 238 142 645 (31) - 209 47.5% (57.0%) IG(V): 37–149 TM: 164–185
zβ1B DQ489723 Chr 16 1054 219 (52) 167 238 142 28 260 (9) 211 49.8% (59.6%) IG(V): 37–149 TM: 164–185
zβ1C DQ489724 Chr 16 574 219 (52) 355 (266) - - - - 105 13.0% (17.5%) IG(V): none TM: none
zβ1D DQ489725 Chr 16 1320 219 (52) 167 238 142 72 (67) 482 (0) 221 53.4% (63.7%) IG(V): 37–149 TM: 164–185
hβ1 NM_001037 Chr 19 1521 231 (40) 167 241 142 72 (67) 668 (0) 218 100% (100%) IG(V): 33–146 TM: 161–182
rβ1A AF182949 Chr 1 850 40 167 643 (615) - - - 273 55.1% (59.1%) IG(V): 33–146 TM: 216–234
hβ1B NM_199037 Chr 19 1170 231 (40) 167 772 (600) - - - 268 58.0% (60.2%) IG(V): 33–146 TM: 244–263
  1. Gene: z = zebrafish, h = human, r = rat, and letters A-D refer to different splice variants. Accession numbers are identifiers for nucleotide sequences in NCBI GenBank. Values for cDNA and exons represent number of nucleotides. (Parentheses) indicate nucleotides within the open reading frame (difference = untranslated sequence or UTR). Protein values represent amino acid number with signal peptide intact. %ID (%SIM) refers to percentage identity and similarity with the human β1 protein sequence as determined by alignment. Zebrafish β subunit topology was determined as described in Methods. IG(V) = V-type immunoglobulin domain and TM = transmembrane domain. Numbering refers to β1 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β1 and human/rat splice variants were annotated based on previous reports [10, 14, 43, 49, 50].