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Table 2 Comparative genomics of the sodium channel β2 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene Genbank accession number gene location cDNA exon 1 exon 2 exon 3 exon 4 exon 5 exon 6 protein %ID (%SIM) topology
zβ2A DQ489726 Chr 15 821 243 (82) 167 411 (234) - - - 160 32.6% (42.5%) IG(V): 47–152 TM: none
zβ2B DQ489727 Chr 15 2449 243 (82) 167 217 196 68 (10) 1558 (0) 223 49.6% (64.7%) IG(V): 47–152 TM: 162–186
zβ2C DQ489728 Chr 15 851 243 (82) 167 217 124 100 (13) - 201 45.2% (58.4%) IG(V): 47–152 TM: 162–186
zβ2D DQ489729 Chr 15 918 243 (82) 167 217 193 98 (34) - 231 48.1% (62.8%) IG(V): 47–152 TM: 162–186
Hsβ2 NM_004588 Chr 11 4939 260 (70) 167 211 4301 (200) - - 215 100% (100%) IG(V): 43–146 TM: 156–180
Mmβ2 NM_001014761 Chr 9 3980 213 (70) 167 211 618 (200) 2771 (0) - 215 92.1% (94.4%) IG(V): 43–146 TM: 156–180
Rnβ2 NM_012877 Chr 8 873 236 (70) 167 211 259 (200) - - 215 93.0% (94.9%) IG(V): 43–146 TM: 156–180
  1. Presentation and labeling as in Table 1. %ID (%SIM) refers to percentage identity and similarity with the human β2 protein sequence as determined by alignment. Zebrafish β2 subunit topology was determined as described in Methods. Numbering refers to β2 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β2 and human/mouse/rat splice variants were annotated based on previous reports [11, 14, 43, 101].