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Table 3 Comparative genomics of the sodium channel β3 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene Genbank accession number gene location cDNA exon 1 exon 2 exon 3 exon 4 exon 5 exon 6 exon 7 protein %ID (%SIM) topology
zβ3 DQ489730 Chr 15 1006 294 (0) 103 (55) 170 235 139 65 (64) - 220 51.1% (65.2%) IG(V): 38–150 TM: 165–186
Hsβ3 NM_018400 Chr 11 4052 778 (0) 80 (55) 164 226 139 86 (64) 2579 (0) 215 100% (100%) IG(V): 38–145 TM: 160–181
Mmβ3 NM_178227 Chr 9 3549 206 (0) 80 (55) 164 226 139 80 (64) 2654 (0) 215 97.7% (97.7%) IG(V): 38–145 TM: 160–181
Rnβ3 NM_139097 Chr 8 3910 350 (0) 82 (55) 164 226 139 80 (64) 2837 (0) 215 98.1% (98.1%) IG(V): 38–145 TM: 160–181
  1. Presentation and labeling as in Table 1. %ID (%SIM) refers to percentage identity and similarity with the human β3 protein sequence as determined by alignment. Zebrafish β3 subunit topology was determined as described in Methods. Numbering refers to β3 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β3 and human/mouse/rat splice variants were annotated based on previous reports [12, 14].