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Table 4 Comparative genomics of the sodium channel β4 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene

Genbank accession number

gene location

cDNA

exon -1

exon 1

exon 2

exon 3

exon 4

exon 5

protein

%ID (%SIM)

topology

zβ4.1

DQ489731

Chr 22

2072

-

597 (91)

164

220

130

961 (94)

232

43.2% (59.3%)

IG(V): 53–155

TM: 165–187

zβ4.2

DQ489732

Chr 5

1490

233 (0)

410 (97)

164

223

130

330 (85)

232

40.8% (56.7%)

IG(V): 55–158

TM: 168–190

Hsβ4

NM_174934

Chr 11

4489

-

214 (61)

173

229

130

3743 (94)

228

100% (100%)

IG(V): 46–151

TM: 162–183

Mmβ4

NM_001013390

Chr 9

4244

-

61

173

229

130

3651 (94)

228

79.4% (88.2%)

IG(V): 46–151

TM: 162–183

Rnβ4

NM_001008880

Chr 8

4272

-

61

173

229

130

3679 (94)

228

80.3% (88.6%)

IG(V): 46–151

TM: 162–183

  1. Presentation and labeling as in Table 1. %ID (%SIM) refers to percentage identity and similarity with the human β4 protein sequence as determined by alignment. Zebrafish β4 subunit topology was determined as described in Methods. Numbering refers to β4 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β4 and human/mouse/rat splice variants were annotated based on previous reports [13, 14].