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Table 4 Comparative genomics of the sodium channel β4 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene Genbank accession number gene location cDNA exon -1 exon 1 exon 2 exon 3 exon 4 exon 5 protein %ID (%SIM) topology
zβ4.1 DQ489731 Chr 22 2072 - 597 (91) 164 220 130 961 (94) 232 43.2% (59.3%) IG(V): 53–155 TM: 165–187
zβ4.2 DQ489732 Chr 5 1490 233 (0) 410 (97) 164 223 130 330 (85) 232 40.8% (56.7%) IG(V): 55–158 TM: 168–190
Hsβ4 NM_174934 Chr 11 4489 - 214 (61) 173 229 130 3743 (94) 228 100% (100%) IG(V): 46–151 TM: 162–183
Mmβ4 NM_001013390 Chr 9 4244 - 61 173 229 130 3651 (94) 228 79.4% (88.2%) IG(V): 46–151 TM: 162–183
Rnβ4 NM_001008880 Chr 8 4272 - 61 173 229 130 3679 (94) 228 80.3% (88.6%) IG(V): 46–151 TM: 162–183
  1. Presentation and labeling as in Table 1. %ID (%SIM) refers to percentage identity and similarity with the human β4 protein sequence as determined by alignment. Zebrafish β4 subunit topology was determined as described in Methods. Numbering refers to β4 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β4 and human/mouse/rat splice variants were annotated based on previous reports [13, 14].