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Table 6 Biophysical properties of zNav1.5 and zNav1.5 plus zβ1 (variant D) in CHO cells.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

  Peak amplitude (pA)* Activation V1/2(mV) Inactivation V1/2(mV) Recovery from inactivation, Tau (ms)
zNa v 1.5 alone -125.7 ± 16.9 pA/pF (n = 8) -47.5 ± 1.6 mV (n = 8) -79.3 ± 1.0 mV (n = 5) 127.9 ± 8.1 ms (n = 4)
zNa v 1.5 + zβ1 -211.1 ± 11.2 pA/pF† (n = 5) -53.0 ± 2.5 mV† (n = 5) -82.6 ± 1.1 mV† (n = 6) 125.7 ± 4.1 ms (n = 6)
  1. All values are mean ± standard error of the mean (SEM). * at a -30 mV depolarizing pulse. † p < 0.001 vs. zNav1.5 alone, Student's T-Test. pA = picoamperes; mV = millivolts; ms = milliseconds; pF = picofahrads; V1/2 = half maximal voltage.