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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Evolution of Class I cytokine receptors

Figure 2

Sea squirt Class I receptor chains. a-b) Sequence alignments. Shown are alignments of the CHD of human (hs) and seasquirt (ci) GP130 (a) and CLF-3 (b) related sequences, with key residues annotated. c) Phylogenetic analysis of sea squirt receptors with representative sequences from each structural group of mammalian receptors and the two fruit fly dome receptors, using the Neighbourhood-Joining algorithm. Bootstrap values are indicated on branches as a percentage of 1000 replicates. d) Splice-site analysis. Schematic representation of the splice structure for the CHD of the above sequences in comparison to the fruit fly (dm) dome. Exons indicated with thick lines and introns with thin connecting lines. Specific residues indicated by standard one letter code.

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