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Figure 6 | BMC Evolutionary Biology

Figure 6

From: Evolution of Class I cytokine receptors

Figure 6

Evolution of Class I cytokine receptors. Class I cytokine receptors are depicted as in Figure 1. The rounded rectangles display all Class I cytokine receptors identified from fruit fly, mosquito, sea squirt, zebrafish, and humans. The bolded rectangles represent the hypothetical receptors present at the time of divergence of protostomes from deuterostomes, urochordates from vertebrates, and ray-finned from lobe-finned fishes, respectively. The vertebrate Class I receptor chains have been further divided into structural groups as described, with the exception of CLF-3 that has been considered separately on the basis of its distinct evolutionary history. Estimation of the times of the key evolutionary events, expressed in millions of years ago (MYA), are based on molecular genomic approaches [56]. Arrows represent presumed evolutionary relationships.

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