Figure 1

Sequence identity patterns in mammalian TLR1 and TLR6. Alignment of parts of the TLR1 and TLR6 amino acid sequences from nine mammalian species: Homo sapiens (HS), Pan troglodytes (PT), Macaca mulatta (Ma), Mus musculus (MM), Rattus norvegicus (RN), Erinaceus europaeus (EE), Bos taurus (BT), Sus scrofa (SS) and Canis familiaris (CF). Amino acids 433 to 473 and 726 to 766 are included as they include the junction sites of three patterns of sequence similarity. The three patterns of identity observed at a particular position are: A) ortholog sequences are more identical; B) paralog sequences are more identical; C) a high over all sequence identity. Color codes: Pattern A) in light blue (or pink): the same amino acid is conserved in 7 or more of 9 ortholog TLR1 (or TLR6) sequences and present in two or less TLR6 (or TLR1) sequences. Pattern B) in red, green, dark blue or grey: the sequences of the TLR1 and TLR6 paralogs are identical in at least seven species; these paralog pairs do not all have the same amino acid at this position. Pattern C) in yellow: the same amino acid is conserved in 14 or more of the 18 TLR1 and TLR6 sequences, patterns A or B do not apply. For the same analysis for the full length TLR1 and TLR6 proteins [see Additional Figure 1].