Figure 3
From: Structural and functional implications of positive selection at the primate angiogenin gene
Map of sites under positive selection and ANG functional regions. The three main functional regions of ANG are represented in the centre image: (i) the ribonucleolytic active site (as determined by superimposition with RNase A [42]) with the main functional amino acid side chains depicted as ball and stick; (ii) the nucleolar location signal and (iii) the "Cell-Binding" site. Lateral images highlight the five structural clusters of sites under positive selection (determined using PAML and TreeSAAP), four of which are located within or in the vicinity of the three main functional regions.