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Figure 9 | BMC Evolutionary Biology

Figure 9

From: Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Figure 9

Relationship between the evolution of eukaryotes and the occurrence of Phox -related regulatory subunits. (A) A phylogeny of eukaryotes was created based largely on genetic information [90, 100]. Branch lengths are for illustrative purposes and are not proportional to phylogenetic distances of groups. Details of deusterostomes are shown in Figure 1. "n.i." indicates none identified or reported. "co-ortho. of v-Nox1-3" indicates that the gene is a co-ortholog ancestor of all members of the vertebrate Nox1-3 subgroup. The number in a parenthesis (e.g. [129, 130, 131]) indicates a reference number. (B) Predicted domains structures of newly identified putative regulatory subunit-like proteins are shown; P, proline-rich region. The sequences are provided in Additional file 7. Abbreviations of domain names are described in legends to other Figures. (C) Sequences of putative AIR-like region are shown. Underlines indicate residues that agree with a consensus sequence of protein kinase C substrate. Bold letters indicate predicted phosphorylation sites in AIR-like regions. Abbreviations: Hs, H. sapiens; Sp, S. purpuratus; Nv, N. vectensis; Lg, L. gigantea; Mb, M. brevicollis.

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