Figure 6
From: Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Activation of Hdm2 and p21 promoters by human and axolotl p53 in AL1 cells. (A-B) Dual-luciferase assays in AL1 cells with Hdm2 and p21 promoters at 25°C. All Luciferase activities were significantly different from non-p53 controls (at least p < 0.05, data not shown). Error bar ± s.e.m. human and axolotl p53 induced luciferase expression were significantly different with the Hdm2 promoter (p < 0.01). Each assay was performed in triplicate at least 3 separate times.