From: Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Human codon | # of mutations reported at this site | Axolotl codon | # of mutations identical to the axolotl sequence | temperature sensitive mutations | scorecons | aa changes at this position S/N/X |
---|---|---|---|---|---|---|
S 37 : TCC | 4 | A : GCA | 0 | Â | 0.35 | +/+/+ |
M 133 : ATG | 49 | L : CTC | 4 | Â | 1 | +/+/+ |
T 150 : ACA | 38 | P : CCG | 1 | Â | 0.39 | -/+/+ |
T 155 : ACC | 128 | A : GCA | 12 | I, N, P | 0.02 | -/+/+ |
V 157: GTC | 267 | L : CTC | 10 | Â | 0 | -/-/+ |
M 160 : ATG | 45 | T : ACT | 0 | I, K, R, T | 0 | -/+/+ |
I 162 : ATC | 59 | V : GTG | 7 | Â | 0 | -/+/+ |
R 174 : AGG | 78 | K : AAA | 12 | Â | 0 | +/+/+ |
S 185 : AGC | 23 | P : CCC | 0 | Â | 0.06 | -/+/+ |
D 186 : GAT | 23 | N : AAT | 5 | Â | 0.01 | -/+/+ |
G 187 : GGT | 42 | D : GAC | 5 | Â | 0.01 | -/+/+ |
L 188 : CTG | 14 | D : GAT | 0 | Â | 0 | -/+/+ |
A 189 : GCC | 41 | S : TCT | 1 | P, S | 0 | -/+/- |
P 191 : CCT | 55 | A : GCC | 0 | Â | 0 | -/+/- |
Q 192 : CAG | 112 | D : GAT | 0 | Â | 0 | -/+/+ |
L 201 : TTG | 33 | F : TTC | 6 | Â | 0.03 | -/+/- |
L 206 : TTG | 20 | K : AAG | 0 | F | 0.01 | -/+/+ |
D 207 : GAT | 23 | M : ATG | 0 | Â | 0 | -/+/+ |
D 208 : GAC | 49 | N : AAT | 6 | A, V | 0 | -/-/- |
R 209 : AGA | 90 | S : TCG | 1 | Â | 0.01 | +/+/+ |
F 212 : TTT | 47 | H : CAT | 0 | V | 0 | -/+/+ |
P 222 : CCG | 32 | T : ACG | 1 | Â | 0.02 | -/+/+ |
E 224 : GAG | 54 | Q : CAG | 0 | Â | 0 | -/+/+ |
V 225 : GTT | 27 | L : CTC | 1 | Â | 0.03 | -/-/- |
D 228 : GAC | 51 | G : GGA | 6 | Â | 0.01 | -/-/+ |
I 232 : ATC | 67 | V : GTG | 6 | F, M | 0 | -/+/+ |
H 233 : CAC | 38 | L : CTT | 2 | Â | 0 | -/+/+ |
D 259 : GAC | 90 | T : ACT | 0 | Â | 0.01 | -/+/+ |
G 262 : GGT | 46 | E : GAG | 0 | Â | 0 | -/-/- |
N 263 : AAT | 24 | Q : CAG | 0 | Â | 0.02 | -/+/+ |
N 268 : AAC | 25 | R : CGC | 0 | I, T | 0.01 | -/+/+ |
S 269 : AGC | 46 | C : TGC | 4 | G, I, R | 0 | -/+/+ |
R 283 : CGC | 126 | K : AAG | 0 | P | 0 | -/+/- |
L 289 : CTC | 32 | F : TTT | 5 | P | 1 | +/+/+ |
F 338 : TTC | 7 | Y : TAT | 0 | S | 0.21 | -/+/+ |
E 343 : GAG | 7 | K : AAG | 0 | G | 0.01 | -/+/+ |
A 353 : GCC | 1 | M : ATG | 0 | P | 0 | +/+/+ |
S 376 : TCT | 2 | P : CCT | 0 | T | 0 | -/+/+ |