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Figure 6 | BMC Evolutionary Biology

Figure 6

From: DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage

Figure 6

Indel rates in 63 GO slim categories. For each GO slim category indel rates were measured in events (insertions+deletions) per 100 kbp in the protein coding regions of all genes assigned to the particular category. The horizontal black line is the average indel rate in all protein coding regions with available GO annotation. We assumed that errors of indel rates are given by Δ r i = N i / L i MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqHuoarcqWGYbGCdaWgaaWcbaGaemyAaKgabeaakiabg2da9maakaaabaGaemOta40aaSbaaSqaaiabdMgaPbqabaaabeaakiabc+caViabdYeamnaaBaaaleaacqWGPbqAaeqaaaaa@386A@ , where N i is the overall number of indels in GO slim category i, and L i is the total length of all protein coding regions assigned to that category. For GO slim categories with N i = 0 errors were obtained by setting N i = 1. The category nucleic acid metabolic process combines nucleobase, nucleoside, nucleotide and nucleic acid metabolic processes.

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