Figure 7From: DNA indels in coding regions reveal selective constraints on protein evolution in the human lineageIdentifying insertion and deletion events. The figure shows an exemplary multiple alignment of orthologous sequence segments in human, chimp and rhesus. The gap containing regions I and D can unambiguously be explained by a single insertion (I) or deletion (D) event in the human lineage since its speciation from the common ancestor with chimp. In contrast, region I* has non-overlapping gaps in chimp and rhesus and therefore requires at least two indel events. These scenarios are always ambiguous. For instance, I* can be explained by an insertion in human and a deletion in chimp, but also by a deletion in chimp and a deletion in rhesus.Back to article page