Figure 6

Ancestral sequence mapping for hydrophiinae group genes. The upper left panel shows the generalized phylogeny while each additional panel shows the cumulative amino acid changes that occurred for that lineage. Amino acids in panels A-E are colored by the lineage they changed in. For example, amino acid changes that occurred in the stem-lineage of neurotoxic genes (lineage C, panel C) are colored X; amino acid changes that occurred in ancestral lineages of neutrotoxins are colored Y and Z. In each panel the top two structures are shown with the molecular surface and the bottom structures are ribbons. Structures on left and right are rotated about a central axis 180°. Cystienes are shown in yellow