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Table 4 Z-scores of free energy. Comparison between each real pre-miRNA and 1,000 random and four types of shuffled pseudo pre-miRNAs

From: In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Species

Random

Zero-markov

Mononucleotide

First-markov

Dinucleotide

H. sapiens

-3.81 ± 1.22

-4.16 ± 1.38

-4.22 ± 1.36

-5.73 ± 1.78

-5.27 ± 1.79

C. elegans

-2.39 ± 1.49

-3.22 ± 1.42

-3.25 ± 1.42

-4.57 ± 2.05

-4.59 ± 2.01

D. melanogaster

-2.20 ± 1.03

-3.42 ± 1.06

-3.43 ± 1.04

-4.57 ± 1.46

-4.61 ± 1.52

D. rerio

-2.74 ± 1.29

-3.40 ± 1.16

-3.51 ± 1.19

-4.61 ± 1.62

-4.37 ± 1.58

M. musculus

-3.48 ± 1.20

-3.75 ± 1.37

-3.74 ± 1.33

-5.12 ± 1.76

-4.62 ± 1.78

R. norvegicus

-3.52 ± 1.25

-3.44 ± 1.26

-3.51 ± 1.29

-4.96 ± 1.74

-4.46 ± 1.77

Average

-3.12 ± 1.37

-3.62 ± 1.32

-3.68 ± 1.32

-4.98 ± 1.78

-4.66 ± 1.76