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Table 4 Z-scores of free energy. Comparison between each real pre-miRNA and 1,000 random and four types of shuffled pseudo pre-miRNAs

From: In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Species Random Zero-markov Mononucleotide First-markov Dinucleotide
H. sapiens -3.81 ± 1.22 -4.16 ± 1.38 -4.22 ± 1.36 -5.73 ± 1.78 -5.27 ± 1.79
C. elegans -2.39 ± 1.49 -3.22 ± 1.42 -3.25 ± 1.42 -4.57 ± 2.05 -4.59 ± 2.01
D. melanogaster -2.20 ± 1.03 -3.42 ± 1.06 -3.43 ± 1.04 -4.57 ± 1.46 -4.61 ± 1.52
D. rerio -2.74 ± 1.29 -3.40 ± 1.16 -3.51 ± 1.19 -4.61 ± 1.62 -4.37 ± 1.58
M. musculus -3.48 ± 1.20 -3.75 ± 1.37 -3.74 ± 1.33 -5.12 ± 1.76 -4.62 ± 1.78
R. norvegicus -3.52 ± 1.25 -3.44 ± 1.26 -3.51 ± 1.29 -4.96 ± 1.74 -4.46 ± 1.77
Average -3.12 ± 1.37 -3.62 ± 1.32 -3.68 ± 1.32 -4.98 ± 1.78 -4.66 ± 1.76