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Table 5 Robustness analysis of miRNA within each species

From: In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Species N s Length %GC No. of genetically robust miRNAs (%) No. of environmentally robust miRNAs (%)
H. sapiens 242 85.48 ± 14.49 47.67 ± 7.88 177(73.1) 233(96.3)
C. elegans 112 98.29 ± 6.42 44.61 ± 6. 89 93(83.0) 74(66.1)
D. melanogaster 75 87.67 ± 12.74 41.60 ± 5.39 54(72.0) 48(64.0)
D. rerio 350 94.36 ± 18.49 45.11 ± 6.51 254(72.6) 254(72.6)
M. musculus 191 80.26 ± 12.48 48.19 ± 8.26 130(68.1) 177(92.7)
R. norvegicus 112 90.96 ± 9.14 50.34 ± 7.96 77(68.8) 105(93.8)
  1. N s , total number of experimentally verified miRNA sequences; Length, distribution of miRNA sequence length; %GC, distribution of GC content of miRNA sequences; No. of genetically (environmentally) robust miRNAs (%), the number of significantly genetically (environmentally) robust miRNAs (%) at FDR-controlled P-value of < 0.05, comparing with random pseudo pre-miRNAs.