In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Table 5 Robustness analysis of miRNA within each species

Species	N _s	Length	%GC	No. of genetically robust miRNAs (%)	No. of environmentally robust miRNAs (%)
H. sapiens	242	85.48 ± 14.49	47.67 ± 7.88	177(73.1)	233(96.3)
C. elegans	112	98.29 ± 6.42	44.61 ± 6. 89	93(83.0)	74(66.1)
D. melanogaster	75	87.67 ± 12.74	41.60 ± 5.39	54(72.0)	48(64.0)
D. rerio	350	94.36 ± 18.49	45.11 ± 6.51	254(72.6)	254(72.6)
M. musculus	191	80.26 ± 12.48	48.19 ± 8.26	130(68.1)	177(92.7)
R. norvegicus	112	90.96 ± 9.14	50.34 ± 7.96	77(68.8)	105(93.8)

N_s, total number of experimentally verified miRNA sequences; Length, distribution of miRNA sequence length; %GC, distribution of GC content of miRNA sequences; No. of genetically (environmentally) robust miRNAs (%), the number of significantly genetically (environmentally) robust miRNAs (%) at FDR-controlled P-value of < 0.05, comparing with random pseudo pre-miRNAs.

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