Table 1 Human Gene Families used in Analysis
From: An insight into the phylogenetic history of HOX linked gene families in vertebrates
Gene family | Members | Chr Location | Human Protein Accession No | Molecular Function |
|---|---|---|---|---|
Fbrillar collagen family | Â | Â | Â | Â |
| Â | COL2A1 | 12q13.11-q13.2 | P02458 | Extracellular matrix structural constituent, Structural constituent of bone, Phosphate transport, Cell adhesion, Skeletal development, Perception of sound. |
| Â | COL3A1 | 2q31 | P02461 | Â |
| Â | COL5A2 | 2q14-q32 | Q7KZ55 | Â |
| Â | COL1A2 | 7q22.1 | P08123 | Â |
| Â | COL1A1 | 17q21.33 | P02452 | Â |
ERBB receptor protein-tyrosine kinase | Â | Â | Â | Â |
| Â | ERBB2 | 17q21.1 | Q96RT1 | Epidermal growth factor receptor activity, Protein serine/threonine kinase activity, Electron transporter activity, Cell proliferation, ATP binding. |
| Â | EGFR | 7p12 | P00533 | Â |
| Â | ERBB4 | 2q33.3-q34 | Q15303 | Â |
| Â | ERBB3 | 12q13 | P21860 | Â |
Insulin-like growth factor-binding protein | Â | Â | Â | Â |
| Â | IGFBP4 | 17q12-q21.1 | P22692 | Regulation of cell growth, Signal transduction, Skeletal development Cell proliferation. |
| Â | IGFBP1 | 7p13-p12 | P08833 | Â |
| Â | IGFBP2 | 2q33-q34 | P18065 | Â |
| Â | IGFBP6 | 12q13 | P24592 | Â |
| Â | IGFBP3 | 7p13-p12 | P17936 | Â |
| Â | IGFBP5 | 2q33-q36 | P24593 | Â |
Integrin beta chain family | Â | Â | Â | Â |
| Â | ITGB3 | 17q21.32 | P05106 | Receptor activity, Cell-matrix adhesion, Integrin-mediated signaling pathway. |
| Â | ITGB5 | 3q21.2 | P18084 | Â |
| Â | ITGB6 | 2q24.2 | P18564 | Â |
| Â | ITGB7 | 12q13.13 | P26010 | Â |
| Â | ITGB4 | 17q25 | P16144 | Â |
| Â | ITGB8 | 7p15.3 | P26012 | Â |
Myosin light chain | Â | Â | Â | Â |
| Â | MYL4 | 17q21-qter | P12829 | Phosphoprotein phosphatase activity, Structural constituent of muscle, Muscle development, Microfilament motor activity. |
| Â | MYL6 | 12q13.2 | P60660 | Â |
| Â | MYL1 | 2q33-q34 | P06741 | Â |
| Â | MYL7 | 7p21-p11.2 | Q01449 | Â |
| Â | MYL2 | 12q23-q24.3 | P10916 | Â |
Sp1 c2h2-type zinc-finger protein family | Â | Â | Â | Â |
| Â | SP1 | 12q13.1 | P08047 | RNA polymerase II transcription factor activity. |
| Â | SP2 | 17q21.32 | Q02086 | Â |
| Â | SP3 | 2q31 | Q02447 | Â |
| Â | SP4 | 7p15 | Q02446 | Â |
| Â | SP8 | 7p21.2 | Q8IXZ3 | Â |
Zinc finger protein, subfamily 1A | Â | Â | Â | Â |
| Â | ZNFN1A1 | 7p13-p11.1 | Q13422 | DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. |
| Â | ZNFN1A2 | 2qter | Q9UKS7 | Â |
| Â | ZNFN1A3 | 17q21 | Q9UKT9 | Â |
| Â | ZNFN1A4 | 12q13 | Q96JP3 | Â |
Anion exchanger family SLC4A (AE) | Â | Â | Â | Â |
| Â | SLC4A1 | 17q21-q22 | P02730 | Inorganic anion exchanger activity, Bicarbonate transport, Chloride transport. |
| Â | SLC4A2 | 7q35-q36 | P04920 | Â |
| Â | SLC4A3 | 2q36 | P48751 | Â |
| Â | SLC4A5 | 2p13 | Q14203 | Â |
| Â | SLC4A8 | 12q13 | O95233 | Â |
| Â | SLC4A10 | 2q23-q24 | Q9HCQ6 | Â |
GLI zinc-finger protein family | Â | Â | Â | Â |
| Â | GLI1 | 12q13.2-q13.3 | P08151 | Regulation of transcription from RNA polymerase II promoter, Morphogenesis of limb and brain. |
| Â | GLI2 | 2q14 | P10070 | Â |
| Â | GLI3 | 7p13 | P10071 | Â |
Hedgehog family | Â | Â | Â | Â |
| Â | SHH | 7q36 | Q15465 | Mesodermal cell fate determination, Proteolysis and peptidolysis, Cell-cell signaling, Intein-mediated protein splicing. |
| Â | DHH | 12q12-q13.1 | O43323 | Â |
| Â | IHH | 2q33-q35 | Q14623 | Â |
Inhibin | Â | Â | Â | Â |
| Â | INHBA | 7p15-p13 | P08476 | Cytokine activity, Growth factor activity, Induction of apoptosis, Mesoderm development, Defense response. |
| Â | INHBB | 2cen-q13 | P09529 | Â |
| Â | INHBC | 12q13.1 | P55103 | Â |
| Â | INHBE | 12q13.3 | P58166 | Â |