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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

Figure 4

Interaction of Ser-949 and His-950 with other residues in human MR. The Ser-949 backbone oxygen and nitrogen form hydrogen bonds with backbone oxygen and nitrogen on nearby residues. Ser-949 Cβ has a van der Waals interaction with Phe-946, Val-954 and Phe-956. The side chain on His-950 is pointed away from the MR core and could interact with proteins that bind to the MR.

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