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Figure 8 | BMC Evolutionary Biology

Figure 8

From: Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes

Figure 8

Site-specific KA/KS analysis of the vertebrate Ugt1 and Ugt2 clusters. Shown are positively selected ω+ sites mapped to the acceptor domain of a ribbon diagram of the UGT71G1 crystal structure [47]. (A) Positively selected sites in the primate and dog UGT1. The ω+ sites for the human only are highlighted in green; for the baboon only, in orange; for the rhesus monkey only, in cyan; for the dog only, in magenta; for the chimpanzee and dog only, in blue; and for all five species, in red. (B) Positively selected sites in the rodent UGT1. The ω+ sites for the mouse only are highlighted in blue; for the rat only, in green; and for both mouse and rat, in red. (C) Positively selected sites in the chicken and zebrafish UGT1. The ω+ sites for the chicken only are highlighted in blue; for the zebrafish cluster Ugt1a only, in magenta; for the zebrafish cluster Ugt1b only, in cyan; for both chicken and zebrafish cluster Ugt1a, in red; and for both zebrafish clusters Ugt1a and Ugt1b, in green. (D) Positively selected sites in the human, mouse, and rat UGT2. The ω+ sites for the human only are highlighted in magenta; for the mouse only, in cyan; for the rat only, in green; for the mouse and rat only, in blue; and for all three species, in red. The residues mapped are comparably numbered according to the sequence of UGT71G1 and are equivalent between UGT1 and UGT2, and among different vertebrate species.

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