Distinguishing importation from diversification of quinolone-resistant Neisseria gonorrhoeae by molecular evolutionary analysis

Table 1 Positively selected amino acid sites (AA site). Sites based on d_N/d_S > 1 under PAML and change in amino acid property by TREESAAP (TS) and absolute amino acid frequencies at those sites in susceptible (AA-S), resistant (AA-R), C3 strain (AA-C3R), and C21\C24 strains (AA-21R/24R). All AA sites including gaps were not included

Locus	AA site^a (PAML)	AA site (TS)	AA-S	AA-R	AA-C3R	AA-21R/24R
abcZ	152	152	14K-10E	21K	E	E
fumC	310		6M-18I	3I-18M	M	I
gdh	253		5G-19S	21S	S	S
glnA	12	12	3K-21E	21K	E	K
glnA	14	14	3K-21E	21K	E	K
glnA	42	42	3G-21D	21G	D	G
glnA	51	51	3Q-21P	21Q	P	Q
glnA	68		3Q-21E	21Q	E	Q
glnA	91		1L-23I	21I	I	I
glnA		151	1I-23T	21T	T	T
gnd	301		2R-22K	21K	K	K
gnd	350	350	10D-14G	1D-20G	D	G
gyrA	91	91	23S-1T	21F	F	F
gyrA	95	95	23D-1N	21N	N	G
parC	86	86	24D	21N	N	N
pilA	181	181	6G-18D	21D	G	D
pilA	273	273	1E-23G	21G	G	E
pilA	284		24T	21A	T	A
ppk	551		4Q-20R	21R	R	R
pyrD		66	1K-23E	21E	E	E
pyrD		72	1D-23G	21G	G	G
serC	37	37	9P-15S	21S	S	P
serC	40	40	9A-15E	21E	E	A
serC	164		3Q-21R	21R	R	R
serC	165	165	3I-21E	21E	E	E
serC	168		3K-21R	21R	R	R
serC		193	1G-23D	21D	D	D
porB	22	22	15K-7G-2D	23K	1K	-
porB	23	23	14D-7A-1G-2S	23D	1D	-
porB		35	22G-2D	23G	1G	-
porB		36	8N-12D-4E	20N-3D	1N	-
porB		42	4K-20G	23G	1G	-
porB	45		5Q-2E-2R-15K	23K	1Q	-
porB	89	89	2Q-22R	23R	1Q	-
porB	91		4N-5S-15G	3G-20N	1S	-
porB		111	2M-22I	23I	1I	-
porB	117	117	2L-3V-2Y-2Q-1D-2S-1T-1D-10F	3F-20V	1A	-
porB	120	120	13V-7I-2S-1T-1M	3V-20I	1I	-
porB	157	157	2Q-22G	23G	1G	-
porB	160	160	5A-2L-17T	3T-20A	1A	-
porB	161	161	3R-2V-2T-17W	3W-20R	1R	-
porB	162	162	2G-1S-21R	23R	1R	-
porB	163	163	5D-2V-17A	23A	1A	-
porB	176		4V-20A	23A	1A	-

^a AA site position numbers based on translated amino acid sequence of gene from strain FA1090, with the exception of porB.

ISSN: 2730-7182