Figure 5

The conserved and species-specific A-to-I RNA editing. Alignment of the homologous exon 5 genomic nucleotide (A) and amino acid (B) sequences of nAChR subunit alpha6 genes from D. melanogaster (Dme), A. gambiae (Aga), H. virescens (Hvi), B. mori (Bmo), T. castaneum (Tca) and A. mellifera (Ame). RNA editing of the nAChR subunit alpha6 genes from D. melanogaster, H. virescens and A. gambiae have been previously described [16, 17]. The editing sites from positions 1–14 (A) and amino acids (B) are shaded in red. Those sites constitutively G (A) and amino acids (B) are shaded in green at the editing sites. RNA editing sites, which were not evidently detected as a mixed sequence signal G and A, but revealed by sequencing of cDNA clones, are underlined.