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Table 1 Mammalian heme peroxidase features and functions (adapted from Clark 2000 and O'Brien 2000).

From: The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions

Superfamily (EC no.)

Chromosomal Location (Human)

Tissue Expression

Biological Function

MPO (1.11.1.7)

17

Neutrophils, mono-nuclear phagocytes

Microbicidal activity

EPO (1.11.1.7)

17

Eosinophils

Microbicidal activity

LPO (1.11.1.7)

17

Milk, saliva, tears and other secretions

Bacteriostatic and bactericidal activity

TPO (1.11.1.8)

2

Thyroid cell surface and cytoplasm

Thyroid hormone biosynthesis

  1. MPO = Myeloperoxidase; EPO = Eosinophil peroxidase; LPO = Lactoperoxidase; TPO = Thyroid peroxidase.