Reducing the false positive rate in the non-parametric analysis of molecular coevolution

Table 3 Coevolution analysis in the heat-shock protein 90.

Group of coevolution	Amino acid sites^a	Mean H(X)^b	Mean H(Y)^c	Mean H(X, Y)^d	Mean MI^e
G1	E244, T458	0.4617	0.3993	0.6336	0.2275
G2	E244, K541	0.4617	0.5573	0.7610	0.2581
G3	E244, Q578	0.4617	0.3602	0.5588	0.2631
G4	V260, A287	0.3247	0.3585	0.4589	0.2243
G5	V260, I520	0.3247	0.3038	0.3605	0.2680
G6	V260, N673	0.3247	0.3220	0.4138	0.2328
G7	A287, K541	0.3585	0.5573	0.6573	0.2585
G8	L450, T688	0.5628	0.4966	0.8183	0.2411
G9	A477, D499	0.3524	0.2251	0.3524	0.2251
G10	A477, N673	0.3524	0.3220	0.4489	0.2256
G11	P482, G555	0.3452	0.4028	0.5027	0.2453
G12	F492, K541	0.3942	0.5573	0.7139	0.2376
G13	I520, G555	0.3038	0.4028	0.4768	0.2298

^a Amino acid sites included in each coevolution group. All sites within the same group coevolve between each other. Numbers indicate the position of the site taking as reference the sequence of Saccharomyces cerevisae.
^b Measure of mean uncertainty for the first site of the coevolving pair.
^c Measure of mean uncertainty for the second site of the coevolving pair.
^d Measure of the mean joined uncertainty for the pairs of sites within each group
^e Mutual Information mean value for all the possible coevolving pairs within the group.

ISSN: 2730-7182