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Table 3 Within-population diversity metrics for DEFB127 and DEFB132. p values are shown when less than 0.05, error values represent standard deviations unless otherwise indicated

From: Directional and balancing selection in human beta-defensins

Gene

Metric

Indigenous Australians

UK

Other sub-Saharan Africans

Mbuti/Biaka

DEFB127

nucleotides

3210

3210

3210

3210

 

Gene Diversity

0.72 +/- 0.089

0.83 +/- 0.057

0.97 +/- 0.036

0.95 +/- 0.033

 

Segregating sites

22

22

13

30

 

Nucleotide diversity (π) ×10-3

2.3 +/- 1.3

3.2 +/- 1.7

1.4 +/- 0.8

1.5 +/- 0.8

 

θH

2.0 +/- 0.93

4.0 +/- 1.8

28 +/- 33

18 +/- 14

 

θs

6.2 +/- 2.4

6.5 +/- 2.5

4.1 +/- 1.8

8.4 +/- 3.2

 

θπ

7.5 +/- 4.1

10 +/- 5.5

4.5 +/- 2.6

4.7 +/- 2.7

 

θk (95% confidence limits)

2.5 (0.97 – 6.2)

4.4 (1.8 – 10)

22 (8 – 66)

19 (8.2 – 47)

 

Fu's Fs

4.63

3.63

-4.35

-5.38 (p = 0.013)

 

Tajima's D

0.82

2.27 (p = 0.030)

0.38

-1.72 (p = 0.030)

 

Fay and Wu's H

-2.31

1.05

-0.13

-9.61 (p = 0.019)

 

Nucleotide divergence human-chimp %

1.2+/-0.2

DEFB132

nucleotides

292

292

292

292

 

Gene Diversity

0.69 +/- 0.11

0.56 +/- 0.063

0.73 +/- 0.10

0.87 +/- 0.048

 

Segregating sites

5

7

7

10

 

Nucleotide diversity (π) ×10-3

6.9 +/- 4.5

5.5 +/- 3.8

7.2 +/- 4.8

10.3 +/- 6.3

 

θH

0.97 +/- 0.25

1.7 +/- 0.87

2.0 +/- 1.1

5.8 +/- 2.7

 

θs

1.1 +/- 0.65

1.4 +/- 0.76

2.5 +/- 1.2

2.5 +/- 1.2

 

θπ

1.6 +/- 1.1

2.0 +/- 1.3

2.1 +/- 1.4

3.0 +/- 1.8

 

θk (95% confidence limits)

0.72 (0.21 – 2.3)

3.4 (1.4 – 8.1)

2.3 (0.81 – 6.4)

4.4 (1.8 – 10)

 

Tajima's D

1.29

1.25

-0.62

0.65

 

Fu's Fs

-1.20

2.51

0.19

-0.83

 

Fay and Wu's H

-0.095

0.35

-2.42

-0.60

 

Nucleotide divergence human-chimp %

2.8+/-1.0

Number of chromosomes

20

20

14

20